Potassium Carbonate → HCID 18673915, compound

HRID 1635998Notes

Reaction equation

HRID 1635998 reaction equation
C(O[N:5]1[C:10]([O:11][C:12]2[CH:13]=[C:14]3[C:19](=[CH:20][CH:21]=2)[CH:18]=[CH:17][CH2:16][CH2:15]3)=[CH:9][CH:8]=[C:7]([NH:22][C:23]([NH:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[O:24])[CH2:6]1)(=O)C.C(=O)([O-])[O-:37].[K+].[K+]>C(O)C>[C:18]1(=[O:37])[C:19]2[C:14](=[CH:13][C:12]([O:11][C:10]3[N:5]=[CH:6][C:7]([NH:22][C:23]([NH:25][C:26]4[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=4)=[O:24])=[CH:8][CH:9]=3)=[CH:21][CH:20]=2)[CH2:15][CH2:16][CH2:17]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69693323HCID 69693323, compound

Product 1

HCID 18673915HCID 18673915, compoundYield 70.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of N1-{1-acetoxy-6-[(3,4-dihydronaphthalene-6-yl)oxy]pyridine-3-yl}-N3-[4-(trifluoromethyl)phenyl]urea (450 mg) in ethanol (20 ml), 980 mg of potassium carbonate was added and the mixture was stirred at room temperature for 40 minutes. After the reaction mixture was filtered and concentrated, the residue was dissolved in ethyl acetate and the solution was washed with water. After drying over anhydrous magnesium sulfate, the solvent was distilled off. The residue was washed with ether to obtain 290 mg of the titled compound as a white powder.

Workup

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationconcentrated
  3. dissolutionthe residue was dissolved in ethyl acetate
  4. washthe solution was washed with water
  5. dry with materialAfter drying over anhydrous magnesium sulfate
  6. distillationthe solvent was distilled off
  7. washThe residue was washed with ether

Sources & evidence

ORD record
ord-14763c3a8a5946b2b143515e470078e3
Source dataset
uspto-grants-2003_01
Patent number
US06511995B1

Reaction notes

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