1-Acetyl-5-bromo-4-chloro-1H-indol-3-yl acetate → HCID 9964843, compound

HRID 1636042Notes

Reaction equation

HRID 1636042 reaction equation
CC([N:4]1[C:8]2[CH:9]=[CH:10][C:11]([Br:14])=[C:12]([Cl:13])[C:7]=2[C:6]([O:15]C(C)=O)=[CH:5]1)=O.C[O-].[Na+]>CN(C)C=O>[Br:14][C:11]1[C:12]([Cl:13])=[C:7]2[C:8](=[CH:9][CH:10]=1)[NH:4][CH:5]=[C:6]2[OH:15]

Participants

4

Reactant 2

HCID 764161-Acetyl-5-bromo-4-chloro-1H-indol-3-yl acetateHCID 10942334Sodium Methoxide

Product 1

HCID 9964843HCID 9964843, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of 5-bromo-4-chloroindoxyl 1,3-diacetate (25) (1.0 g, 3.03 mmol) in anhydrous N,N-dimethylformamide (3 mL) was added sodium methoxide (270 mg, 5.00 mmol). The resulting dark-colored reaction mixture was degassed with nitrogen (g) for 30 min at room temperature.

Workup

  1. customThe resulting dark-colored reaction mixture was degassed with nitrogen (g) for 30 min at room temperature

Sources & evidence

ORD record
ord-3792561cbc854554bc8ffb2d9fa37dfc
Source dataset
uspto-grants-2003_01
Patent number
US06512100B1

Reaction notes

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