Potassium Hydroxide → HCID 22743447, compound

HRID 1636054Notes

Reaction equation

HRID 1636054 reaction equation
CS([O:5][CH:6]([CH3:35])[CH:7]([N:9]1[C:13](=[O:14])[N:12]([C:15]2[CH:20]=[CH:19][C:18]([N:21]3[CH2:26][CH2:25][N:24]([C:27]4[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=4)[CH2:23][CH2:22]3)=[CH:17][CH:16]=2)[CH:11]=[N:10]1)[CH3:8])(=O)=O.[OH-].[K+]>CO.O1CCCC1>[OH:5][CH:6]([CH3:35])[CH:7]([N:9]1[C:13](=[O:14])[N:12]([C:15]2[CH:16]=[CH:17][C:18]([N:21]3[CH2:22][CH2:23][N:24]([C:27]4[CH:28]=[CH:29][C:30]([O:33][CH3:34])=[CH:31][CH:32]=4)[CH2:25][CH2:26]3)=[CH:19][CH:20]=2)[CH:11]=[N:10]1)[CH3:8]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 23383640HCID 23383640, compound

Product 1

HCID 22743447HCID 22743447, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
100 °C

Procedure

According to the precedure described in Nakamura et al. (J.A.C.S. 1985, 107 p2138), intermediate 5d (0.001 mol) was added to a solution of KOH (0.03 g) in CH3OH (7ml) and tetrahydrofuran (3 ml). The mixture was stirred at 100° C. for 4 hours, yielding [S-(R*,R*)]-2,4-dihydro-2-(2-hydroxy-1-methylpropyl)-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one (interm. 5c).

Sources & evidence

ORD record
ord-4484f220c4c442bcbe3e8684fa27b23e
Source dataset
uspto-grants-2003_01
Patent number
US06512116B2

Reaction notes

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