Hydrochloric Acid → HCID 18674686, compound

HRID 1636064Notes

Reaction equation

HRID 1636064 reaction equation
[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([N:11]([CH2:18][CH2:19][CH3:20])[C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:3]=1.Cl>CCOCC>[ClH:1].[Cl:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]([N:11]([CH2:18][CH2:19][CH3:20])[C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10979011HCID 10979011, compound

Product 1

HCID 18674686HCID 18674686, compoundYield 87.6%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a 4 g sample of product, 3-chloro-N-propyl-N-4-pyridinyl-1H-indol-1-amine, dissolved in anhydrous ether (60 mL) in a 125 mL-round bottom flask equipped with a mechanical stirrer, thermometer and dropping funnel, was added slowly an ethereal solution saturated with hydrogen chloride (6 mL) at room temperature, under a nitrogen atmosphere, with stirring. After about 0.5 hrs at room temperature, the precipitate was collected, washed with anhydrous ether (15 mL) and dried to yield 3.95 g (87.6%) of product.

Workup

  1. customequipped with a mechanical stirrer
  2. customthe precipitate was collected
  3. washwashed with anhydrous ether (15 mL)
  4. customdried

Sources & evidence

ORD record
ord-12764e9d84db4627a7cd807c004ea3aa
Source dataset
uspto-grants-2003_01
Patent number
US06512125B1

Reaction notes

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