HCID 86586541, compound → HCID 10156794, compound

HRID 1636065Notes

Reaction equation

HRID 1636065 reaction equation
C([O:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][NH:9][C:10](=[O:35])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][O:18][C:19]1[CH:34]=[CH:33][C:22]2[O:23][CH2:24][C:25]3[CH:32]=[CH:31][CH:30]=[CH:29][C:26]=3[C:27](=[O:28])[C:21]=2[CH:20]=1

Participants

4

Reactant 1

HCID 86586541HCID 86586541, compound

Product 1

HCID 10156794HCID 10156794, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

400 mg (0.845 mmol) 8-(11-Oxo-6,11-dihydro-dibenzo[b,e]oxepin-2 yloxy)-octanoic acid benzyloxyamide in 50 ml methanol was hydrogenated in the presence of palladium on calcium carbonate at ambient temperature and pressure. The catalyst was removed by filtration and the solvent was evaporated. The residue was purified by column chromatography (methanol/water 75:25). There was thus obtained 90 mg (28%) of the title compound as an amorphous solid. MS: 382 (M−H+); 384 (M+H+).

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated
  3. customThe residue was purified by column chromatography (methanol/water 75:25)

Sources & evidence

ORD record
ord-9450982f2fc1429b88f10c77f65d4f73
Source dataset
uspto-grants-2003_01
Patent number
US06512123B2

Reaction notes

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