反应详情

N-tert-Butylhydroxylamine hydrochloride (19.7 g, 98%, 0.15 mol) was dissolved in water (40 g) at +20° C. Ethyl acetate (118 g) and sodium acetate (19.3 g, 0.24 mol, 1.5 equiv.) were added. A slurry was formed initially but then dissolved. After 2 h the bluish organic phase was separated and concentrated giving an opaque, yellow oil (20.6 g, 88%) that solidified upon standing in the refrigerator. Chromatographic purity (GC): 97.0 area %.

1. customA slurry was formed initially
2. dissolutiondissolved
3. customAfter 2 h the bluish organic phase was separated
4. concentrationconcentrated