Hydrochloric Acid → HCID 54315819, compound

HRID 1636111Notes

Reaction equation

HRID 1636111 reaction equation
C([O:5][C:6]([C@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:23])[CH2:14][O:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([OH:22])[CH:17]=1)=[O:7])(C)(C)C.Cl>ClCCl.O1CCOCC1>[OH:22][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][CH:19]=1)[O:15][CH2:14][C:13]([N:9]1[CH2:10][CH2:11][CH2:12][C@@H:8]1[C:6]([OH:7])=[O:5])=[O:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 53845804HCID 53845804, compound

Product 1

HCID 54315819HCID 54315819, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 120 mg (0.37 mmol)) (R)-1-[(3-hydroxy-phenoxy)-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester in 1 ml dichloromethane were added 5 ml of a 4 N solution of hydrochloric acid in dioxane. After 3 d, the solvent was removed in vacuo and the residue suspended in 10 ml ether. The resulting suspension was stirred overnight. Filtration and drying gave 95 mg (97%) of the title compound as a white powder.

Workup

  1. customthe solvent was removed in vacuo
  2. filtrationFiltration
  3. customdrying

Sources & evidence

ORD record
ord-81fc7b41806a46c7a76d6fa4882cb893
Source dataset
uspto-grants-2003_01
Patent number
US06512001B1

Reaction notes

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