HCID 69895204, compound → HCID 69895768, compound

HRID 1636124Notes

Reaction equation

HRID 1636124 reaction equation
C([O:5][C:6]([C@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:42])[CH2:14][O:15][C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][C:20]([O:26][CH2:27][C:28]([N:30]3[CH2:34][CH2:33][CH2:32][C@@H:31]3[C:35]([O:37]C(C)(C)C)=[O:36])=[O:29])=[CH:21][CH:22]=2)[CH:17]=1)=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:35]([C@H:31]1[CH2:32][CH2:33][CH2:34][N:30]1[C:28](=[O:29])[CH2:27][O:26][C:20]1[CH:19]=[C:18]2[C:23]([CH:24]=[CH:25][C:16]([O:15][CH2:14][C:13]([N:9]3[CH2:10][CH2:11][CH2:12][C@@H:8]3[C:6]([OH:7])=[O:5])=[O:42])=[CH:17]2)=[CH:22][CH:21]=1)([OH:37])=[O:36]

Participants

3

Reactant 1

HCID 69895204HCID 69895204, compound

Product 1

HCID 69895768HCID 69895768, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 272 mg (0.47 mmol) (R)-1-[[7-[2-[(R)-2-tert-butoxycarbonyl-pyrrolidin-1-yl)-2-oxo-ethoxy]-naphthalen-2-yloxy]-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester in 1.5 ml trifluoroacetic acid was stirred for 4 h at room temperature. The solvent was removed in vacuo and the residue suspended in 10 ml ether. The resulting suspension was stirred overnight. Filtration and drying gave 209 mg (95%) of the title compound as a white powder.

Workup

  1. customThe solvent was removed in vacuo
  2. filtrationFiltration
  3. customdrying

Sources & evidence

ORD record
ord-cfc56ed7a21d485eb395f97c62a4c034
Source dataset
uspto-grants-2003_01
Patent number
US06512001B1

Reaction notes

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