HCID 54051372, compound → HCID 53921737, compound

HRID 1636128Notes

Reaction equation

HRID 1636128 reaction equation
C([O:5][C:6]([C@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1[C:13](=[O:42])[CH2:14][N:15]([CH2:38][CH2:39][CH2:40][CH3:41])[C:16]([N:18]([CH2:23][C:24]([N:26]1[CH2:30][CH2:29][CH2:28][C@@H:27]1[C:31]([O:33]C(C)(C)C)=[O:32])=[O:25])[CH2:19][CH2:20][CH2:21][CH3:22])=[O:17])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[C:31]([C@H:27]1[CH2:28][CH2:29][CH2:30][N:26]1[C:24](=[O:25])[CH2:23][N:18]([CH2:19][CH2:20][CH2:21][CH3:22])[C:16](=[O:17])[N:15]([CH2:14][C:13]([N:9]1[CH2:10][CH2:11][CH2:12][C@@H:8]1[C:6]([OH:7])=[O:5])=[O:42])[CH2:38][CH2:39][CH2:40][CH3:41])([OH:33])=[O:32]

Participants

3

Reactant 1

HCID 54051372HCID 54051372, compound

Product 1

HCID 53921737HCID 53921737, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of 278 mg (0.47 mmol) (R)-1-[[3-[2-[(R)-2-tert-butoxycarbonyl-pyrrolidin-1-yl]-2-oxo-ethyl]-1,3-dibutyl-ureido]-acetyl]-pyrrolidine-2-carboxylic acid tert-butyl ester in 2 ml trifluoroacetic acid was stirred for 4 h at room temperature. The solvent was removed in vacuo and the residue was dried to give 167 mg (74%) of the title compound as brown foam.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue was dried

Sources & evidence

ORD record
ord-de5df2f92c374576a30994d73aae007f
Source dataset
uspto-grants-2003_01
Patent number
US06512001B1

Reaction notes

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