Chloroform → 4-[4-(1,2,3,4-Tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-yl]pyridine-3-carboxylic acid methyl ester

HRID 163616Notes

Reaction equation

HRID 163616 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][c:10]2[cH:11][c:12]([O:18][CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([c:26]4[c:27]([C:32](=[O:33])[O:34][CH3:35])[cH:28][n:29][cH:30][cH:31]4)[CH2:24][CH2:25]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1)([CH3:5])([CH3:6])[CH3:7].[CH:43]([Cl:44])([Cl:45])[Cl:46].[OH:36][C:37]([C:38]([F:39])([F:40])[F:41])=[O:42]>>[NH:8]1[CH2:9][c:10]2[cH:11][c:12]([O:18][CH2:19][CH:20]3[CH2:21][CH2:22][N:23]([c:26]4[c:27]([C:32](=[O:33])[O:34][CH3:35])[cH:28][n:29][cH:30][cH:31]4)[CH2:24][CH2:25]3)[cH:13][cH:14][c:15]2[CH2:16][CH2:17]1

Participants

4

Reactant 3

HCID 6212ChloroformHCID 6422Trifluoroacetic acidHCID 112024757-[1-(3-Methoxycarbonylpyridin-4-yl)piperidin-4-ylmethoxy]-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester

Product 1

HCID 600641694-[4-(1,2,3,4-Tetrahydroisoquinolin-7-yloxymethyl)piperidin-1-yl]pyridine-3-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-a84b0afcdd64465893d2fd88f8b8c24b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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