Acetic Acid → HCID 19350832, compound

HRID 1636290Notes

Reaction equation

HRID 1636290 reaction equation
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][O:14][CH:13]([N:16]2[CH:26]=[CH:25][C:20]([NH:21]C(=O)C)=[N:19][C:17]2=[O:18])[CH2:12][S:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O-].[Na+].C(O)(=O)C>CO>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][O:14][CH:13]([N:16]2[CH:26]=[CH:25][C:20]([NH2:21])=[N:19][C:17]2=[O:18])[CH2:12][S:11]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 10942334Sodium MethoxideHCID 54154960HCID 54154960, compound

Product 1

HCID 19350832HCID 19350832, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-(5-Benzyloxymethyl-1,4-oxathian-2-yl)-N4 -acetylcytosine (0.31 g) was dissolved in methanol (10 ml), and 0.43M sodium methoxide solution (1 ml) was added to the solution. The resultant mixture was stirred at room temperature for one hour to complete the reaction. The reaction mixture was neutralized with acetic acid, and the solvent was removed by evaporation under reduced pressure to obtain pale yellow solid.

Workup

  1. customthe reaction
  2. customthe solvent was removed by evaporation under reduced pressure
  3. customto obtain pale yellow solid

Sources & evidence

ORD record
ord-ddf0298f547a43dbac15bfc46c7a9cb3
Source dataset
uspto-grants-2000_03
Patent number
US06034087

Reaction notes

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