HCID 19350799, compound → HCID 19350821, compound

HRID 1636301Notes

Reaction equation

HRID 1636301 reaction equation
C([O:4][CH2:5][CH:6]1[CH2:11][O:10][CH:9]([N:12]2[CH:20]=[C:18]([CH3:19])[C:16](=[O:17])[NH:15][C:13]2=[O:14])[CH2:8][CH2:7]1)(=O)C>N.CO>[OH:4][CH2:5][CH:6]1[CH2:11][O:10][CH:9]([N:12]2[CH:20]=[C:18]([CH3:19])[C:16](=[O:17])[NH:15][C:13]2=[O:14])[CH2:8][CH2:7]1

Participants

4

Reactant 1

HCID 19350799HCID 19350799, compound

Product 1

HCID 19350821HCID 19350821, compoundYield 53.7%

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Procedure

1-(5-Acetoxymethyltetrahydropyran-2-yl)thymine (0.07 g) was dissolved in a saturated ammonia solution in methanol, and the mixture stirred overnight. After removing the solvent by evaporation under reduced pressure from the mixture, the residue was purified on a silica gel column (eluent: chloroform/methanol=15/1) to obtain the desired product (0.032 g, 52%) as white solid.

Workup

  1. customAfter removing the solvent
  2. customby evaporation under reduced pressure from the mixture
  3. customthe residue was purified on a silica gel column (eluent: chloroform/methanol=15/1)

Sources & evidence

ORD record
ord-759bc034271540afbb8590942f586158
Source dataset
uspto-grants-2000_03
Patent number
US06034087

Reaction notes

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