Hydrochloric Acid → HCID 136197556, compound

HRID 1636302Notes

Reaction equation

HRID 1636302 reaction equation
C([O:4][CH2:5][CH:6]1[CH2:11][O:10][CH:9]([N:12]2[CH:20]=[N:19][C:18]3[C:17](=[O:21])[NH:16][C:15]([NH:22]C(=O)C)=[N:14][C:13]2=3)[CH2:8][CH2:7]1)(=O)C.C[O-].[Na+].Cl>CO>[OH:4][CH2:5][CH:6]1[CH2:11][O:10][CH:9]([N:12]2[CH:20]=[N:19][C:18]3[C:17](=[O:21])[NH:16][C:15]([NH2:22])=[N:14][C:13]2=3)[CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 136023925HCID 136023925, compound

Product 1

HCID 136197556HCID 136197556, compoundYield 74.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

9-(5-Acetoxymethyltetrahydropyran-2-yl)-N2 -acetylguanine (80 mg) was dissolved in dried methanol, and catalytic amount of sodium methoxide was added thereto. After stirring at room temperature overnight, the mixture was neutralized with methanolic hydrochloric acid and concentrated under reduced pressure. The residue was purified on a silica gel column (eluent: chloroform/methanol=7/1) to obtain the desired product (45 mg, 73%) as pale gray solid.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was purified on a silica gel column (eluent: chloroform/methanol=7/1)

Sources & evidence

ORD record
ord-fac4ad6c91844c7e905a4dee42ca7896
Source dataset
uspto-grants-2000_03
Patent number
US06034087

Reaction notes

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