HCID 19350728, compound → HCID 19350717, compound

HRID 1636314Notes

Reaction equation

HRID 1636314 reaction equation
Cl.[NH2:2][N:3]1[CH:7]=[C:6]([CH3:8])[N:5]([CH3:9])[C:4]1=[O:10].[H][H]>CO.[Rh]>[NH2:2][N:3]1[CH2:7][CH:6]([CH3:8])[N:5]([CH3:9])[C:4]1=[O:10]

Participants

5

Reactant 2

HCID 19350728HCID 19350728, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 19350717HCID 19350717, compound

Reagents, catalysts & solvents 2

HCID 23948RhodiumCatalystHCID 887MethanolSolvent

Procedure

1.6 g of Rh/C are added to a solution of 1-amino-3,4-dimethyl-2-oxo-1,3-dihydroimidazole hydrochloride in 150 ml of methanol and the reaction mixture is hydrogenated with hydrogen under normal pressure. After 4 hours, 1.13 litres of hydrogen have been taken up and the reaction ceases. The reaction mixture is then filtered over Celite and concentrated by evaporation. The residue is stirred with tetrahydrofuran. The crystals are filtered off with suction and dried in vacuo at 60°. 7 g of the title compound in the form of the hydrochloride having a melting point of 162-164° are obtained.

Workup

  1. customthe reaction ceases
  2. filtrationThe reaction mixture is then filtered over Celite
  3. concentrationconcentrated by evaporation
  4. filtrationThe crystals are filtered off with suction
  5. customdried in vacuo at 60°

Sources & evidence

ORD record
ord-e1232a05dac441ac97834d37da383adf
Source dataset
uspto-grants-2000_03
Patent number
US06034083

Reaction notes

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