3-Pyridinecarboxaldehyde → HCID 2823965, compound

HRID 1636316Notes

Reaction equation

HRID 1636316 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=O)[CH:2]=1.[NH2:9][NH:10][C:11]([NH:13][NH2:14])=[O:12]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[N:9][NH:10][C:11]([NH:13][N:14]=[CH:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[O:12])[CH:2]=1

Participants

4

Reactant 2

HCID 103713-PyridinecarboxaldehydeHCID 73948Carbohydrazide

Product 1

HCID 2823965HCID 2823965, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

32.2 g of pyridine-3-carbaldehyde are added in the course of approx. 10 minutes, at room temperature, to a suspension of 13.5 g of carbohydrazide in 200 ml of methanol, the temperature rising to more than 35°. The reaction mixture is further stirred for 1 hour and then cooled to 5°. The crystals that precipitate are filtered off with suction and dried in vacuo at 70°. 40 g of the title compound having a melting point of 202-204° are thus obtained.

Workup

  1. customrising to more than 35°
  2. temperaturecooled to 5°
  3. filtrationThe crystals that precipitate are filtered off with suction
  4. customdried in vacuo at 70°
  5. customare thus obtained

Sources & evidence

ORD record
ord-e5a66d70dfc24ad2ad2233b9aba76a5b
Source dataset
uspto-grants-2000_03
Patent number
US06034083

Reaction notes

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