反应详情

55 g of potassium carbonate are added to a solution of 26.4 g of 5-methoxy-3H-[1,3,4]-thiadiazol-2-one in 700 ml of dioxane and the reaction mixture is heated to 60°. Then 35 g of bromomethyl cyclopropyl ketone are added dropwise within a short period of time and the reaction mixture is stirred at 70° for 20 hours and then, at 20°, is filtered over Celite. The filtrate is concentrated by evaporation. The residue is stirred with diisopropyl ether and filtered with suction. 41 g of crystals of the title compound having a melting point of 98-100° are thus obtained.

1. temperaturethe reaction mixture is heated to 60°
2. filtrationat 20°, is filtered over Celite
3. concentrationThe filtrate is concentrated by evaporation
4. stirringThe residue is stirred with diisopropyl ether
5. filtrationfiltered with suction
6. customare thus obtained