Phenylacetyl chloride → 4-bromophenyl phenylacetate

HRID 1636430Notes

Reaction equation

HRID 1636430 reaction equation
[C:1]1([CH2:7][C:8](Cl)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1>N1C=CC=CC=1>[C:1]1([CH2:7][C:8]([O:18][C:15]2[CH:16]=[CH:17][C:12]([Br:11])=[CH:13][CH:14]=2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7679Phenylacetyl chlorideHCID 78084-Bromophenol

Product 1

HCID 7954544-bromophenyl phenylacetate

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Phenylacetyl chloride (9.4 g) was added dropwise to 4-bromophenol (10 g) in pyridine, and the reaction mixture was stirred at room temperature for 1 hour then evaporated to dryness under reduced pressure. The residue was taken up in ethyl acetate, washed with water, dried over magnesium sulfate, filtered and evaporated under reduced pressure to give 4-bromophenyl phenylacetate.

Workup

  1. customthen evaporated to dryness under reduced pressure
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e62b875f07344a7cb60eaca24d96a755
Source dataset
uspto-grants-2000_03
Patent number
US06034121

Reaction notes

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