Hydrochloric Acid → HCID 19351633, compound

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Reaction Steps

A mixture of 6-bromo-4-chloro-3-propyl-2H-1-benzopyran-2-one (0.5 g) with sodium hydride (0.8 g of 60% in oil) and 4-methoxyphenol (0.24 g) in dry dimethylformamide (5 ml) was stirred at room temperature overnight under nitrogen. The mixture was poured into dilute hydrochloric acid and extracted with diethyl ether. The extracts were washed with sodium hydroxide, brine, dried and evaporated under reduced pressure. The residue was triturated with light petroleum (b.p. 40-60° C.) to give 6-bromo-4-(4-methoxyphenoxy)-3-propyl-2H-1-benzopyran-2-one, m.p. 104-6° C. (compound 20).

Provenance & Evidence