反应详情

A mixture of 6-bromo-4-chloro-3-propyl-2H-1-benzopyran-2-one (0.5 g) with sodium hydride (0.8 g of 60% in oil) and 4-methoxyphenol (0.24 g) in dry dimethylformamide (5 ml) was stirred at room temperature overnight under nitrogen. The mixture was poured into dilute hydrochloric acid and extracted with diethyl ether. The extracts were washed with sodium hydroxide, brine, dried and evaporated under reduced pressure. The residue was triturated with light petroleum (b.p. 40-60° C.) to give 6-bromo-4-(4-methoxyphenoxy)-3-propyl-2H-1-benzopyran-2-one, m.p. 104-6° C. (compound 20).

1. extractionextracted with diethyl ether
2. washThe extracts were washed with sodium hydroxide, brine
3. customdried
4. customevaporated under reduced pressure
5. customThe residue was triturated with light petroleum (b.p. 40-60° C.)