Water → HCID 19351607, compound

HRID 1636438Notes

Reaction equation

HRID 1636438 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.[C:9](Cl)(=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].O>N1C=CC=CC=1>[C:9]([O:8][C:5]1[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=1)(=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]

Participants

5

Reactant 3

HCID 962WaterHCID 78084-BromophenolHCID 17313Heptanoyl chloride

Product 1

HCID 19351607HCID 19351607, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A solution of 4-bromophenol (20 g) in dry pyridine (75 ml) was cooled to 0° C. and heptanoyl chloride (18.79 ml) was added dropwise. The mixture was stirred at room temperature for 21/2 hours. Water (10 ml) was added to dissolve the precipitate and the mixture then evaporated under reduced pressure. The residue was dissolved in diethyl ether, washed with water, hydrochloric acid, water, aqueous saturated sodium hydrogen carbonate, water, dried and evaporated under reduced pressure to give 4-bromophenyl heptanoate.

Workup

  1. dissolutionto dissolve the precipitate
  2. customthe mixture then evaporated under reduced pressure
  3. dissolutionThe residue was dissolved in diethyl ether
  4. washwashed with water, hydrochloric acid, water, aqueous saturated sodium hydrogen carbonate, water
  5. customdried
  6. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-fe75d65f297c42cc8a4a4b9955d5962b
Source dataset
uspto-grants-2000_03
Patent number
US06034121

Reaction notes

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