反应详情

2-(4'-amino-3'-iodophenyl)benzothiazole (0.123 g, 0.35 mmol) was treated with copper (I) cyanide (63 mg, 0.7 mmol) in DMF according to procedure for preparation of 2-(4'-amino-3'-chlorophenyl) benzothiazole. The crude product was purified by chromatography on silica gel, eluting with ethyl acetate-hexane (2:3) to give a pale yellow powder (0.032 g, 36%%), m.p. 207.3-211.0° C.

1. customThe crude product was purified by chromatography on silica gel
2. washeluting with ethyl acetate-hexane (2:3)
3. customto give a pale yellow powder (0.032 g, 36%%), m.p. 207.3-211.0° C.