Chloroacetyl chloride → HCID 19352176, compound

HRID 1636562Notes

Reaction equation

HRID 1636562 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[Cl:17]CC(Cl)=O.[Cl:22][CH2:23][C:24](NC1C=CC(C2SC3C=CC=CC=3N=2)=CC=1)=[O:25]>C1C=CC=CC=1>[ClH:17].[Cl:22][CH2:23][C:24]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:9][C:10]3[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:7]=1)=[O:25]

Participants

5

Reactant 3

HCID 6577Chloroacetyl chlorideHCID 88733Benzenamine, 4-(2-benzoxazolyl)-HCID 385071HCID 385071, compound

Product 1

HCID 19352176HCID 19352176, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

2-(4'-Aminophenyl)benzoxazole (0.28 g, 1.33 mmol) was treated with chloroacetyl chloride (0.5 ml) in benzene (15 ml) according to the procedure described above for preparation of 2-(4'-chloroacetamidophenyl)benzothiazole. 2-(4'-Chloroacetamidophenyl)benzoxazole hydrochloride was obtained (0.31 g, 72%).

Sources & evidence

ORD record
ord-65420691235d4d3f95025ab355bdcbe8
Source dataset
uspto-grants-2000_03
Patent number
US06034246

Reaction notes

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