反应详情

A solution of N-[2-(5-bromo-6-(2-propynyl)oxyindan-1-yl)ethyl]propionamide (2.9 g, 8.4 mmol.) in bromobenzene (30 mL) was stirred for 18 hours in a sealed tube at 200° C. The reaction mixture was cooled and, then, the solvent was distilled off under reduced pressure. The residue was purified by means of silica gel column chromatography (ethyl acetate) to afford the title compound (yield 2.5 g, 85%).

1. temperatureThe reaction mixture was cooled
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by means of silica gel column chromatography (ethyl acetate)