Isopropylamine → HCID 19352247, compound

HRID 1636630Notes

Reaction equation

HRID 1636630 reaction equation
[C:1]1([CH:7]2[O:12][C:10](=[O:11])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:13]([NH2:16])([CH3:15])[CH3:14]>>[OH:12][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][CH2:9][C:10]([NH:16][CH:13]([CH3:15])[CH3:14])=[O:11]

Participants

3

Reactant 2

HCID 6363IsopropylamineHCID 13884gamma-Phenyl-gamma-butyrolactone

Product 1

HCID 19352247HCID 19352247, compoundYield 100.4%

Procedure

A mixture of γ-phenyl-γ-butyrolactone (10.0 g, 61.7 mmol) and isopropylamine (50 ml, 587 mmol) was stirred at room temperature for approximately 26 hours. The solvent was removed under reduced pressure to give 4-hydroxy-N-isopropyl-4-phenyl-butyramide (13.71 g, 100%) as a yellow solid, mp 131-135° C.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-4093c317ee8d45cab44bfd25b7d6b17f
Source dataset
uspto-grants-2000_03
Patent number
US06034272

Reaction notes

Loading…