Potassium Carbonate → HCID 10907050, compound

HRID 1636738Notes

Reaction equation

HRID 1636738 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][C:11]=2[S:17][CH3:18])=[O:9])=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].[Br:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br>CC(C)=O>[Br:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][O:16][C:13]1[CH:14]=[CH:15][C:10]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)=[O:9])=[C:11]([S:17][CH3:18])[CH:12]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 123681,6-DibromohexaneHCID 10925342HCID 10925342, compound

Product 1

HCID 10907050HCID 10907050, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

450 mg of (4-bromo-phenyl)-(4-hydroxy-2-methylsulphanyl-phenyl)-methanone are taken up in 7 ml of acetone and treated with 1.24 g of K2CO3 and 530 μl of 1,6-dibromohexane. The suspension is heated under reflux overnight, cooled, filtered and concentrated. After removing the excess 1,6-dibromohexane there are obtained 710 mg of [4-[6-(bromo)-hexyloxy]-2-methylsulphanyl-phenyl]-(4-bromo-phenyl)-methanone as a brown oil.

Workup

  1. temperatureThe suspension is heated
  2. temperatureunder reflux overnight
  3. temperaturecooled
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customAfter removing the excess 1,6-dibromohexane

Sources & evidence

ORD record
ord-2c5c924463914828a45e673308ddbc35
Source dataset
uspto-grants-2000_03
Patent number
US06034275

Reaction notes

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