4-Aminobenzonitrile → HCID 54190091, compound

HRID 1636778Notes

Reaction equation

HRID 1636778 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[NH2:10][C@H:11]1[CH2:15][CH2:14][N:13]([CH2:16]C2C=C(C=CC=2O)C#N)[C:12]1=[O:26].[Cl:27][C:28]1[C:36]2[CH:35]=[C:34]([S:37](Cl)(=[O:39])=[O:38])[S:33][C:32]=2[CH:31]=[C:30](Cl)[CH:29]=1>>[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[CH2:16][N:13]1[CH2:14][CH2:15][C@H:11]([NH:10][S:37]([C:34]2[S:33][C:32]3[CH:31]=[CH:30][CH:29]=[C:28]([Cl:27])[C:36]=3[CH:35]=2)(=[O:39])=[O:38])[C:12]1=[O:26]

Participants

4

Reactant 3

HCID 133964-AminobenzonitrileHCID 10659497HCID 10659497, compoundHCID 19350936HCID 19350936, compound

Product 1

HCID 54190091HCID 54190091, compound

Procedure

The title compound is prepared as described in EXAMPLE 17, Part G, substituting 3-[3-(S)-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-amino-benzonitrile for 3-[(3-(S)-amino-2-oxo-pyrrolidin-1-yl)-methyl]-4-hydroxy-benzonitrile and substituting 4-chlorobenzo[b]thiophene-2-sulfonyl chloride for 4,6-dichlorobenzo[b]thiophene-2-sulfonyl chloride. The crude product is triturated with Et2O to give the product as a white solid. FAB MS, [M+H]+ =461, 463, Cl pattern.

Workup

  1. customThe crude product is triturated with Et2O

Sources & evidence

ORD record
ord-cc09ae9fe4fc4985a557444691e29f9e
Source dataset
uspto-grants-2000_03
Patent number
US06034093

Reaction notes

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