Thionyl Chloride → HCID 19349446, compound

HRID 1636806Notes

Reaction equation

HRID 1636806 reaction equation
O[CH2:2][C:3]1[CH:4]=[C:5]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])[CH:6]=[C:7]([CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:8]=1.S(Cl)([Cl:22])=O>ClCCl>[ClH:22].[Cl:22][CH2:2][C:3]1[CH:4]=[C:5]([C:15]([CH3:19])([CH3:18])[C:16]#[N:17])[CH:6]=[C:7]([CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:8]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19349435HCID 19349435, compound

Product 1

HCID 19349446HCID 19349446, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of the product from Example 27 (1 g) and thionyl chloride (0.4 ml) in dichloromethane (5 ml) was heated under reflux for 0.5 h, then evaporated to dryness under reduced pressure, to give 2-[3-chloromethyl-5-(1H-1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile hydrochloride, mp. 189°-190° after trituration with ethyl acetate.

Workup

  1. temperatureunder reflux for 0.5 h
  2. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-3a69181eeb584b4ebfda81cb5e3f0499
Source dataset
uspto-grants-2000_03
Patent number
USRE036617

Reaction notes

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