Dimethylformamide → HCID 86744038, compound

Participants

Reaction Steps

A mixture of 2,2'-[5-bromocyanomethyl-1,3-phenylene]di(2-methylpropiononitrile) (0.33 g), 1,2,4-triazole (0.34 g) and dimethylformamide (2 ml) was stirred at 50° for 24 h. The mixture was treated with water (20 ml), and extracted with ethyl acetate, and the extract was dried and evaporated to dryness under reduced pressure. The residue was purified by flash chromatography, using methanol (3% by volume) in dichloromethane as eluant, to give 2,2'-[5-cyano(1H-1,2,4-triazol-1-yl)methyl-1,3-phenylene]di(2-methylpropiono-nitrile), characterised as the hydrochloride salt, mp 148°-151°.

Provenance & Evidence