Dimethylformamide → HCID 86744038, compound

HRID 1636819Notes

Reaction equation

HRID 1636819 reaction equation
Br[C:2]1[CH:3]=[C:4]([C:16]([CH3:20])([CH3:19])[C:17]#[N:18])[C:5]([CH2:13]C#N)=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#[N:10])[CH:7]=1.[NH:21]1[CH:25]=[N:24][CH:23]=[N:22]1.[CH3:26][N:27](C)C=O>O>[C:26]([C:2]1[CH:3]=[C:4]([C:16]([CH3:20])([CH3:19])[C:17]#[N:18])[C:5]([CH2:13][N:21]2[CH:25]=[N:24][CH:23]=[N:22]2)=[C:6]([C:8]([CH3:11])([CH3:12])[C:9]#[N:10])[CH:7]=1)#[N:27]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 92571H-1,2,4-TriazoleHCID 19349433HCID 19349433, compound

Product 1

HCID 86744038HCID 86744038, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2,2'-[5-bromocyanomethyl-1,3-phenylene]di(2-methylpropiononitrile) (0.33 g), 1,2,4-triazole (0.34 g) and dimethylformamide (2 ml) was stirred at 50° for 24 h. The mixture was treated with water (20 ml), and extracted with ethyl acetate, and the extract was dried and evaporated to dryness under reduced pressure. The residue was purified by flash chromatography, using methanol (3% by volume) in dichloromethane as eluant, to give 2,2'-[5-cyano(1H-1,2,4-triazol-1-yl)methyl-1,3-phenylene]di(2-methylpropiono-nitrile), characterised as the hydrochloride salt, mp 148°-151°.

Workup

  1. extractionextracted with ethyl acetate
  2. customthe extract was dried
  3. customevaporated to dryness under reduced pressure
  4. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-60f94e6dcfbb4cc1b2349096fcb66817
Source dataset
uspto-grants-2000_03
Patent number
USRE036617

Reaction notes

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