Hydrochloric Acid → HCID 178429330, compound

Participants

Reaction Steps

Ethyl acetoacetate (13 g) and ethyl cyanoacetate (11.3 g) were added sequentially to a mixture of neo-pentanolamine (25.7 g) and water (5 cm3) keeping the temperature <10C. The mixture was then refluxed for 16 hrs before drowning into water (50 cm3). The aqueous solution was acidified with hydrochloric acid. The pinkish coloured solid which precipitated on stirring for several hours was isolated by filtration, washed with water and dried under reduced pressure. Yield -13.1 g

Provenance & Evidence