Hydrochloric Acid → HCID 178429330, compound

HRID 1636839Notes

Reaction equation

HRID 1636839 reaction equation
[C:1]([O:7]CC)(=O)[CH2:2][C:3]([CH3:5])=O.[C:10]([CH2:12][C:13](OCC)=[O:14])#[N:11].[CH3:18][C:19]([CH2:23][OH:24])([CH2:21][NH2:22])[CH3:20].Cl>O>[C:10]([C:12]1[C:13](=[O:14])[N:22]([CH2:21][C:19]([CH3:20])([CH3:18])[CH2:23][OH:24])[C:1]([OH:7])=[CH:2][C:3]=1[CH3:5])#[N:11]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7764Ethyl cyanoacetateHCID 8868Ethyl AcetoacetateHCID 1173261-Propanol, 3-amino-2,2-dimethyl-

Product 1

HCID 178429330HCID 178429330, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

Ethyl acetoacetate (13 g) and ethyl cyanoacetate (11.3 g) were added sequentially to a mixture of neo-pentanolamine (25.7 g) and water (5 cm3) keeping the temperature <10C. The mixture was then refluxed for 16 hrs before drowning into water (50 cm3). The aqueous solution was acidified with hydrochloric acid. The pinkish coloured solid which precipitated on stirring for several hours was isolated by filtration, washed with water and dried under reduced pressure. Yield -13.1 g

Workup

  1. temperatureThe mixture was then refluxed for 16 hrs
  2. customThe pinkish coloured solid which precipitated
  3. customwas isolated by filtration
  4. washwashed with water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-8e8b49164d13456fbbb2df8456100bf9
Source dataset
uspto-grants-2000_03
Patent number
US06037309

Reaction notes

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