1-Methylpiperazine → 5-Chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole

HRID 1636864Notes

Reaction equation

HRID 1636864 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8](S)=[N:7][C:6]=2[CH:11]=1.[CH3:13][N:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH3:12])[C:5]2[O:9][C:8]([N:17]3[CH2:18][CH2:19][N:14]([CH3:13])[CH2:15][CH2:16]3)=[N:7][C:6]=2[CH:11]=1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 178426087HCID 178426087, compound

Product 1

HCID 106117595-Chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

5-Chloro-7-methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylpiperazine (0.55 ml) was added dropwise to the solution and then the mixture was stirred with heating for 3 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1) to obtain the title compound 5-chloro-7-methyl-2-(4-methyl-1-piperazinyl)benzoxazole (270 mg).

Workup

  1. temperaturewith heating for 3 days
  2. customAfter evaporation of the solvent
  3. customthe thus obtained mixture was purified by a silica gel column chromatography (methylene chloride:methanol=20:1)

Sources & evidence

ORD record
ord-3d30eddc79e046b8bf6bc82c2370112a
Source dataset
uspto-grants-2000_03
Patent number
US06037342

Reaction notes

Loading…