反应详情

A portion (200 mg) of the compound obtained in Example 81 was suspended in methylene chloride (10 ml) and to the suspension were added 2-nitrobenzoyl chloride (0.18 ml) and triethylamine (0.11 ml) under cooling with ice. The mixture was stirred for 30 minutes at room temperature. n-Hexane was added to the reaction mixture, and the crystals were collected by filtration and washed with water and n-hexane successively to yield 260 mg (81%) of the titled compound as brown crystals.

1. temperatureunder cooling with ice
2. filtrationthe crystals were collected by filtration
3. washwashed with water and n-hexane successively