Hydrochloric Acid → 5-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochloride

HRID 1637282Notes

Reaction equation

HRID 1637282 reaction equation
[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1.[ClH:20]>C(O)C>[ClH:20].[NH2:1][CH:2]1[C:12]2[C:13]3[C:5](=[C:6]([C:14]4[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=4)[NH:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 101988185-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole

Product 1

HCID 193483565-Amino-2-phenyl-1,3,4,5-tetrahydrobenz[cd]indole hydrochlorideYield 76%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A portion (1.0 g) of the compound obtained in Example 81 was suspended in ethanol (10 ml) and to the suspension was added a solution (2.5 ml) of 20% hydrochloric acid in ethanol. The mixture was stirred for 10 minutes at room temperature. The reaction mixture was concentrated under reduced pressure. The crystals obtained were washed with ether and ether/methanol to yield 0.87 g (76%) of the titled compound as pale brown crystals.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customThe crystals obtained
  3. washwere washed with ether and ether/methanol

Sources & evidence

ORD record
ord-d6fba87e077448f9ad96bfde303fbda8
Source dataset
uspto-grants-2000_03
Patent number
US06040331

Reaction notes

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