Pyrrolidine → HCID 19348384, compound

HRID 1637286Notes

Reaction equation

HRID 1637286 reaction equation
[C:1]([N:4]1[C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[CH:13](Br)[CH2:14][CH2:15][CH:6]([C:7]=23)[CH:5]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:3])[CH3:2].[NH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[C:1]([N:4]1[C:12]2[CH:11]=[CH:10][CH:9]=[C:8]3[CH:13]([N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[CH2:14][CH2:15][CH:6]([C:7]=23)[CH:5]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 19348335HCID 19348335, compound

Product 1

HCID 19348384HCID 19348384, compoundYield 76%

Procedure

The compound (500 mg) obtained in Example 187 and pyrrolidine (0.24 ml) were subjected to amination according to the procedure of Example 134 to yield 370 mg (76%) of the titled compound as a white powder.

Sources & evidence

ORD record
ord-03846bfd78594ecaa1c4d484957dd7ef
Source dataset
uspto-grants-2000_03
Patent number
US06040331

Reaction notes

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