Triethylamine hydrochloride → HCID 178515941, compound

HRID 1637356Notes

Reaction equation

HRID 1637356 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])#[N:2].[N-:10]=[N+:11]=[N-:12].[Na+].Cl.C(N(CC)CC)C>C1(C)C=CC=CC=1>[OH:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:1]1[NH:12][N:11]=[N:10][N:2]=1

Participants

5

Reactant 3

HCID 11130Triethylamine hydrochlorideHCID 119072-HydroxybenzonitrileHCID 33557Sodium Azide

Product 1

HCID 178515941HCID 178515941, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Into the same device as used in Example 1 were placed 5.96 g (0.050 mole) of orthocyanophenol, 9.76 g (0.150 mole) of sodium azide, 20.65 g (0.150 mole) of triethylamine hydrochloride and 60 ml of toluene. The mixture was reacted for 5 hours in the same manner as in Example 1, giving 7.95 g (0.049 mole) of 5-(2-hydroxyphenyl)-1H-tetrazole (yield 98.0% based on orthocyanophenol).

Workup

  1. customThe mixture was reacted for 5 hours in the same manner as in Example 1

Sources & evidence

ORD record
ord-39aaf59c3c14490c8cb903f9e62b6be8
Source dataset
uspto-grants-2000_03
Patent number
US06040454

Reaction notes

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