Toluene → HCID 178418369, compound

HRID 1637360Notes

Reaction equation

HRID 1637360 reaction equation
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:9]=[N+:10]=[N-:11].[Na+].Cl.C(N(CC)CC)C.C1(C)C=CC=CC=1>O>[C:2]1([C:1]2[NH:11][N:10]=[N:9][N:8]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 1140TolueneHCID 7505BenzonitrileHCID 11130Triethylamine hydrochlorideHCID 33557Sodium Azide

Product 1

HCID 178418369HCID 178418369, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into the same device as used in Example 1 were placed 5.16 g (0.050 mole) of benzonitrile, 4.23 g (0.065 mole) of sodium azide, 8.95 g (0.065 mole) of triethylamine hydrochloride, 52 ml of toluene and 2.6 g of water. The mixture was reacted at a temperature of 85 to 95° C. for 8 hours, giving 6.12 g (0.042 mole) of 5-phenyl-1H-tetrazole (yield 83.7% based on benzonitrile).

Workup

  1. customThe mixture was reacted at a temperature of 85 to 95° C. for 8 hours

Sources & evidence

ORD record
ord-cca3d3bfb4334b04abd786a5ccc3ce82
Source dataset
uspto-grants-2000_03
Patent number
US06040454

Reaction notes

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