4-Nitrobenzyl chloroformate → 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-nitrobenzyloxy)carbonyl]hydrazine

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Reaction Steps

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-nitrobenzyloxy)carbonyl]hydrazine (compound 10h) was prepared by reacting compound 2 with 4-nitrobenzyl chloroformate using a procedure similar to that employed for compound 10d. The product was recrystallized from ethanol, and the yield was approximately 22.9% by weight. The Mp was approximately 132-133° C. 1H NMR (acetone-d6): δ 8.3 and 7.8 (4H, 2d, aromatic H), 5.6 (2H, s, ArCH2), 3.6-4.2 (4H, m, CH2CH2Cl), 3.6 and 3.3 (6H, 2s, 2 CH3SO2).

Provenance & Evidence