4-Chloro-2-nitrobenzyl alcohol → 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-chloro-2-nitrobenzyloxy)carbonyl]hydrazine

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Reaction Steps

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(4-chloro-2-nitrobenzyloxy)carbonyl]hydrazine (compound 13b) was prepared from 4-chloro-2-nitrobenzyl alcohol using a procedure similar to that described for compound 13a. The Mp was about 120-121° C., and the yield was approximately 40.0% by weight after recrystallization from ethanol. 1H NMR (acetone-d6): δ 8.2 and 7.7-8.0 (3H, s, m, aromatic H), 5.8 (2H, d, ArCH2), 3.6-4.1 (4H, m, CH2CH2Cl), 3.5 and 3.2 (6H, 2s, 2 CH3SO2).

Provenance & Evidence