5-Chloro-2-nitrobenzyl alcohol → 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(5-chloro-2-nitrobenzyloxy)carbonyl]hydrazine

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Reaction Steps

1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[(5-chloro-2-nitrobenzyloxy)carbonyl]hydrazine (compound 13c) was prepared from 5-chloro-2-nitrobenzyl alcohol using a procedure similar to that described for compound 13a. The Mp was approximately 100-102° C., and the yield was approximately 14.6% by weight after recrystallization from ethanol. 1H NMR (acetone-d6): δ 8.2, 8.0 and 7.7 (3H, 2d, s, aromatic H), 5.8 (2H, d, ArCH2), 3.6-4.1 (4H, m, CH2CH2Cl), 3.5 and 3.2 (6H, 2s, 2 CH3SO2).

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