反应详情

To a solution of thioglycoside 39 (1.10 g, 2.5 mmol) in 50 mL of MeOH is added K2CO3 in small portions, until the reaction mixture tested basic to pH paper (pH 11). The reaction mixture is stirred at room temperature for 15 min and then neutralized with Amberlite resin (acid form). The resin is removed by filtration and washed with MeOH (2×50 mL). The filtrates are concentrated and azeotroped from toluene to remove the residue MeOH to afford 1-deoxy-1-(phenylthio)-β-D-galactopyranose which is taken on to the next step without further purification.

1. customThe resin is removed by filtration
2. washwashed with MeOH (2×50 mL)
3. concentrationThe filtrates are concentrated
4. customazeotroped from toluene
5. customto remove the residue MeOH