4-Aminopyridine → HCID 19348741, compound

HRID 1637473Notes

Reaction equation

[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([OH:13])=O)=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[C:28]([O:29][CH3:30])=[CH:27][CH:26]=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:4])([CH3:3])[CH3:2].[NH2:34][C:35]1[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=1>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:13])[NH:34][C:35]2[CH:40]=[CH:39][N:38]=[CH:37][CH:36]=2)=[CH:7][C:6]=1[NH:14][C:15](=[O:33])[CH2:16][CH:17]([C:23]1[C:28]([O:29][CH3:30])=[CH:27][CH:26]=[CH:25][C:24]=1[O:31][CH3:32])[CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 17274-Aminopyridine

HCID 19348457HCID 19348457, compound

Product 1

HCID 19348741HCID 19348741, compound

Procedure

Following a similar procedure to that described in Example 8, but using N-(2-t-butyl-5-carboxyphenyl)-3-(2,6-dimethoxyphenyl)octanamide (prepared as described in Preparation 74E) and 4-aminopyridine, the title compound was obtained as colorless crystals, melting at 169-172° C.

Sources & evidence

ORD record: ord-c1112000371a4f79b250af02077581ad
Source dataset: uspto-grants-2000_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06040339

Reaction notes

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