2-Bromoethyl ethyl ether → HCID 19348707, compound

HRID 1637536Notes

Reaction equation

HRID 1637536 reaction equation
[Cl:1][C:2]1[C:3]([OH:21])=[CH:4][C:5]([O:19][CH3:20])=[C:6]([CH:8]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:9][C:10]([O:12]C)=[O:11])[CH:7]=1.[CH2:22]([O:24][CH2:25][CH2:26]Br)[CH3:23]>CCOCC>[Cl:1][C:2]1[C:3]([O:21][CH2:23][CH2:22][O:24][CH2:25][CH3:26])=[CH:4][C:5]([O:19][CH3:20])=[C:6]([CH:8]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[CH2:9][C:10]([OH:12])=[O:11])[CH:7]=1

Participants

4

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 19348427HCID 19348427, compound

Product 1

HCID 19348707HCID 19348707, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Following a similar procedure to that described in Preparation 45a-(i), but using methyl 3-(5-chloro-4-hydroxy-2-methoxyphenyl)octanoate (prepared as described in Preparation 56A) and 2-ethoxyethyl bromide, the corresponding ether derivative was obtained. Hydrolysis of this derivative and subsequent treatment of the reaction mixture were conducted in a similar manner to that described in Preparation 7 to give the title compound as an oily substance.

Workup

  1. customthat described in Preparation 45a-(i)
  2. customHydrolysis of this derivative and subsequent treatment of the reaction mixture
  3. customdescribed in Preparation 7

Sources & evidence

ORD record
ord-2eb86f7d42f94daab934500cca463789
Source dataset
uspto-grants-2000_03
Patent number
US06040339

Reaction notes

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