1,3-Dibromopropane → Methyl 3-[4-(3-bromopropoxy)-2-methoxyphenyl]heptanoate

HRID 1637558Notes

Reaction equation

HRID 1637558 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1.[Br:20][CH2:21][CH2:22][CH2:23]Br>>[Br:20][CH2:21][CH2:22][CH2:23][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([O:18][CH3:19])[CH:3]=1

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 19348616Methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate

Product 1

HCID 19348496Methyl 3-[4-(3-bromopropoxy)-2-methoxyphenyl]heptanoate

Procedure

Following a similar procedure to that described in Preparation 45A(i), but using methyl 3-(4-hydroxy-2-methoxyphenyl)heptanoate (prepared as described in Preparation 58A) and 1,3-dibromopropane, methyl 3-[4-(3-bromopropoxy)-2-methoxyphenyl]heptanoate was obtained as an oily substance.

Workup

  1. customthat described in Preparation 45A(i)

Sources & evidence

ORD record
ord-7a8a94b8a7684f6eadb04f1310ddd605
Source dataset
uspto-grants-2000_03
Patent number
US06040339

Reaction notes

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