反应详情

8.0 g (40.3 mmol) of 6-chloro-3-nitroimidazo[1,2-b]pyridazine, 16.7 g (60.4 mmol) of triphenyl-methanethiol and 16.7 g (120 mmol) of potassium carbonate in 150 ml of dioxane are heated to 90° C. for 5 h under an argon atmosphere. After cooling to room temperature, the mixture is filtered and the filtrate is concentrated. The residue is dissolved in a little ethyl acetate and treated with 100 ml of diisopropyl ether. After 18 h, the crystalline precipitate is filtered off and dried. 12.69 g (72%) of the title compound are isolated. M.p.: 168-170° C.

1. filtrationthe mixture is filtered
2. concentrationthe filtrate is concentrated
3. dissolutionThe residue is dissolved in a little ethyl acetate
4. additiontreated with 100 ml of diisopropyl ether
5. filtrationthe crystalline precipitate is filtered off
6. customdried