2-(Methylamino)ethanol → 2-[(2-Hydroxymethyl-pyridin-4-yl)-methyl-amino]-ethanol

HRID 1637626Notes

Reaction equation

HRID 1637626 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[CH:3]=1.[CH3:10][NH:11][CH2:12][CH2:13][OH:14]>>[OH:9][CH2:8][C:4]1[CH:3]=[C:2]([N:11]([CH3:10])[CH2:12][CH2:13][OH:14])[CH:7]=[CH:6][N:5]=1

Participants

3

Reactant 2

HCID 80162-(Methylamino)ethanolHCID 2763167(4-Chloropyridin-2-yl)methanol

Product 1

HCID 187993842-[(2-Hydroxymethyl-pyridin-4-yl)-methyl-amino]-ethanol

Conditions

Temperature
140 °C

Procedure

A mixture of (4-chloro-pyridin-2-yl)-methanol (20.0 g, 139 mmol) and 2-methylaminoethanol (11.7 ml, 146 mmol) is stirred for 1 h at 140° C. After cooling to room temperature the viscous oil is employed without additional purification for the synthesis described in step b).

Workup

  1. temperatureAfter cooling to room temperature the viscous oil
  2. customis employed without additional purification for the synthesis

Sources & evidence

ORD record
ord-e858c021fed64fee910963edc0e67db3
Source dataset
uspto-grants-2000_03
Patent number
US06043242

Reaction notes

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