2-(Methylamino)ethanol → 2-[(2-Hydroxymethyl-pyridin-4-yl)-methyl-amino]-ethanol

Participants

Reaction Conditions

Reaction Steps

A mixture of (4-chloro-pyridin-2-yl)-methanol (20.0 g, 139 mmol) and 2-methylaminoethanol (11.7 ml, 146 mmol) is stirred for 1 h at 140° C. After cooling to room temperature the viscous oil is employed without additional purification for the synthesis described in step b).

Provenance & Evidence