反应详情

4-Chlorocrotonyl chloride (1.36 g, 9.80 mmol) in ether (20 ml) is combined with diethylamine in ether (5 ml) at -15° C. in a flame dried flask. The reaction is warmed to ambient temperature, stirred for 1 to 2 hours, quenched with water (30 ml), extracted with ethyl acetate (2×30 ml), washed with saline (30 ml), dried over sodium sulfate, and concentrated in vacuo to yield the crude 4-chloro-N,N-diethylcrotonamide.

1. customdried flask
2. customquenched with water (30 ml)
3. extractionextracted with ethyl acetate (2×30 ml)
4. washwashed with saline (30 ml)
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo