Methyl iodide → HCID 492832, compound

HRID 1637736Notes

Reaction equation

HRID 1637736 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[CH3:11])[N:3]=1.[Si](OC1C=C(O[Si](C(C)(C)C)(C)C)N=C(SC(C2C=CC=CN=2)C)N=1)(C(C)(C)C)(C)[CH3:19].CI>>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)([CH3:19])[CH3:11])[N:3]=1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 492831HCID 492831, compoundHCID 18799741HCID 18799741, compound

Product 1

HCID 492832HCID 492832, compound

Procedure

Following the procedure for the preparation of 4-amino-6-chloro-2-(1-(2-pyridyl)ethyl)thio-pyrimidine but employing an additional alkylation of 4,6-di-(tert-butyldimethylsilyloxy)-2-(1-(2-pyridyl)ethyl)thio-pyrimidine with methyl iodide, this compound is prepared. Melting Pt. 183-184.5° C.

Workup

  1. customthis compound is prepared

Sources & evidence

ORD record
ord-8fdd653a33d24087a74e6654bf1218d3
Source dataset
uspto-grants-2000_03
Patent number
US06043248

Reaction notes

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