Trifluoroacetic acid → HCID 3908817, compound

HRID 1637880Notes

Reaction equation

HRID 1637880 reaction equation
[F:1][C:2]1[CH:13]=[C:12]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.[CH2:14]1[O:24][C:23]2[CH:22]=[CH:21][C:18]([CH:19]=O)=[CH:17][C:16]=2[O:15]1.C(O)(C(F)(F)F)=O>>[CH2:14]1[O:24][C:23]2[CH:22]=[CH:21][C:18]([CH:19]3[C:7]4[NH:6][C:5]5[C:12](=[CH:13][C:2]([F:1])=[CH:3][CH:4]=5)[C:8]=4[CH2:9][CH2:10][NH:11]3)=[CH:17][C:16]=2[O:15]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 8438PiperonalHCID 1646825-Fluorotryptamine

Product 1

HCID 3908817HCID 3908817, compoundYield 85%

Procedure

This product was prepared using the same procedure as for Intermediate 1 with 5-fluorotryptamine (1.59 g, 8.9 mmol), 3,4-methylenedioxybenzaldehyde (1.47 g, 1.1 equiv.) and TFA (1.4 mL, 2 equiv.) to give the title compound (2.34 g, 85%) as white crystals. MP: 172° C.

Workup

  1. customThis product was prepared

Sources & evidence

ORD record
ord-aeca22db27ed488ebae40152d740f90a
Source dataset
uspto-grants-2000_03
Patent number
US06043252

Reaction notes

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